What does it cost?
A single IV session in Tennessee typically runs $350 to $600, and a first course is usually six sessions. Spravato is different, because it is normally billed through insurance.
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Independent, sourced information for people in Nashville, Memphis, Knoxville and across Tennessee — written for patients and families, and dated so you can see how current it is.
What it costs in Tennessee Does TennCare cover it?
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Based on published pricing and coverage rules as of 2019-03-05. Sources for every figure this tool can show:
Only esketamine (Spravato) is FDA-approved to treat depression. Racemic ketamine given by IV, injection, or under the tongue has no FDA approval for any psychiatric condition and is used off-label — that is, an approved drug used for an unapproved purpose. as of 30 Apr 2025 · U.S. Food and Drug Administration (source 1, opens in a new tab)
Under Original Medicare Part B in 2026 you pay a $283 yearly deductible first, and after that you generally pay 20% of the Medicare-approved amount for covered services. as of 1 Jan 2026 · Centers for Medicare and Medicaid Services (source 2, opens in a new tab)Deductible and premium amounts are set annually and change each January.
The FDA approved Spravato (esketamine) nasal spray on 5 March 2019, for use with an oral antidepressant, for adults with treatment-resistant depression. as of 5 Mar 2019 · U.S. Food and Drug Administration (source 3, opens in a new tab)
Spravato is available only through a restricted safety programme called a Risk Evaluation and Mitigation Strategy (REMS), and may only be given in a certified healthcare setting under a provider's direct observation. Patients never take it home. as of 30 Apr 2025 · U.S. Food and Drug Administration (source 6, opens in a new tab)
Best available information: Spravato's list price is not published by the manufacturer or in any free public source. At launch in 2019 the wholesale acquisition cost was around $590 for a 56 mg dose and $885 for an 84 mg dose, and the current list price is very likely higher. as of 5 Mar 2019 · Drugs.com (source 7, opens in a new tab)Wholesale acquisition cost is published only in paywalled pricing compendia. The figures here are seven years old and come from a secondary source, so we do not use them to produce a dollar estimate — the estimator suppresses Spravato cash figures rather than presenting a number this weak.
Spravato does not appear on TennCare's preferred drug list or its clinical criteria at all. That is not the same as TennCare refusing to cover it: TennCare routes medicines that a provider administers to the medical benefit, where your own managed care organisation decides coverage rather than the pharmacy list. The practical answer is to ask your TennCare plan, not your pharmacy. as of 15 Jul 2026 · State of Tennessee, Division of TennCare (source 8, opens in a new tab)We confirmed the absence by searching the full text of both TennCare documents. The conclusion that coverage sits with the managed care organisation follows from the preferred drug list's own stated rule for provider-administered medicines.
Best available information: Few Tennessee clinics publish a price for intramuscular ketamine. One Nashville practice lists $225 for the injection; across the state a band of roughly $200 to $450 a session is plausible but largely inferred. as of 18 Jul 2026 · Nashville Psychedelic Center (source 10, opens in a new tab)One published Tennessee price supports the low end of this band. The rest is inference, so treat the range as wide on purpose.
Cash-pay IV ketamine infusions for depression in Tennessee typically run about $350 to $600 for a standard forty-to-sixty minute session. Longer infusions used for chronic pain are priced separately and cost considerably more. as of 18 Jul 2026 · Published Tennessee clinic price lists (source 11, opens in a new tab)The clinic sets the price. Treat this as a guide to what a reasonable answer sounds like, not as a quote.
Best available information: No Tennessee clinic we checked publishes a price for sublingual or lozenge ketamine. Nationally, at-home telehealth programmes advertise from roughly $165 to $430 a session, but we have no Tennessee figure. as of 5 May 2026 · HealingMaps (source 12, opens in a new tab)This is a national figure from a secondary directory, not a Tennessee price. Ask separately what the medicine costs and what the supervised session costs — they are billed differently.
Best available information: Tennessee clinics effectively do not publish self-pay Spravato prices. Those offering it bill the medicine through insurance or list only a monitoring fee, so a self-pay patient has to ask for an individual quote. as of 18 Jul 2026 · Published Tennessee clinic pricing pages (source 13, opens in a new tab)Our estimator does not produce a self-pay Spravato figure, because there is no Tennessee evidence strong enough to build one on.
The Spravato withMe savings programme is not available to anyone using a state or federal government health programme, including Medicare, Medicaid, TRICARE, the Department of Defense, and the Veterans Administration. as of 18 Jul 2026 · Johnson & Johnson (source 16, opens in a new tab)
Through the Spravato withMe savings programme, eligible patients with commercial insurance may pay as little as $10 per treatment for the medicine itself, subject to yearly maximum benefits and quantity limits. as of 18 Jul 2026 · Johnson & Johnson (source 17, opens in a new tab)The programme covers the medicine, not the office visit or the two-hour observation, which is often the larger share of the bill. The official terms state that a yearly maximum applies but do not publish the amount, so we do not either. Terms are set per calendar year.
A single IV session in Tennessee typically runs $350 to $600, and a first course is usually six sessions. Spravato is different, because it is normally billed through insurance.
Spravato is generally covered with prior approval, including by TennCare. IV ketamine is off-label and almost never covered, whoever your insurer is.
We list 36 clinicians registered in Tennessee whose specialty is associated with ketamine therapy — and we are clear about what that does and does not tell you.
| Treatment | FDA status | Where and how long | Typical course | Insurance | Driving | Typical cash cost |
|---|---|---|---|---|---|---|
| IV ketamine infusion | Not FDA-approved for depression (off-label) | In a clinic, usually 40–60 minutes plus recovery | Typically six sessions over two to three weeks | Almost never covered | You will need someone to drive you home | $350–$600 |
| Spravato (esketamine) | FDA-approved for treatment-resistant depression | Self-administered nasal spray in a certified clinic, with two hours of monitoring | Twice weekly for four weeks, then less often | Usually billed through insurance, with prior approval | No driving until the next day, after a night of restful sleep | Depends on your coverage |
| IM injection | Not FDA-approved for depression (off-label) | In a clinic, shorter than an infusion | Varies by clinic | Almost never covered | You will need someone to drive you home | $200–$450 |
| Sublingual or lozenge | Not FDA-approved for depression (off-label) | At home, or in a supervised session | Varies widely by programme | Almost never covered | Do not drive after a dose | $165–$430 |
Only esketamine (Spravato) is FDA-approved to treat depression. Racemic ketamine given by IV, injection, or under the tongue has no FDA approval for any psychiatric condition and is used off-label — that is, an approved drug used for an unapproved purpose. as of 30 Apr 2025 · U.S. Food and Drug Administration (source 1, opens in a new tab)
Cash-pay IV ketamine infusions for depression in Tennessee typically run about $350 to $600 for a standard forty-to-sixty minute session. Longer infusions used for chronic pain are priced separately and cost considerably more. as of 18 Jul 2026 · Published Tennessee clinic price lists (source 11, opens in a new tab)The clinic sets the price. Treat this as a guide to what a reasonable answer sounds like, not as a quote.
Best available information: Few Tennessee clinics publish a price for intramuscular ketamine. One Nashville practice lists $225 for the injection; across the state a band of roughly $200 to $450 a session is plausible but largely inferred. as of 18 Jul 2026 · Nashville Psychedelic Center (source 10, opens in a new tab)One published Tennessee price supports the low end of this band. The rest is inference, so treat the range as wide on purpose.
Best available information: No Tennessee clinic we checked publishes a price for sublingual or lozenge ketamine. Nationally, at-home telehealth programmes advertise from roughly $165 to $430 a session, but we have no Tennessee figure. as of 5 May 2026 · HealingMaps (source 12, opens in a new tab)This is a national figure from a secondary directory, not a Tennessee price. Ask separately what the medicine costs and what the supervised session costs — they are billed differently.
After a Spravato dose you must not drive or operate machinery until the next day, following a restful night's sleep, so you need to arrange a ride home from every session. as of 30 Apr 2025 · U.S. Food and Drug Administration (source 5, opens in a new tab)
The state's population and healthcare centre. Nashville's hospital and academic medical corridor is where the great majority of Tennessee's ketamine and Spravato providers are.
Nashville · Clarksville · Murfreesboro
A valley-and-ridge corridor running from the Tri-Cities through Knoxville to Chattanooga, with several established clinics but long mountain drive times from the surrounding rural counties.
Knoxville · Chattanooga · Johnson City
Centred on Memphis at the Mississippi River, serving a catchment that reaches into Arkansas and Mississippi, with comparatively few openly priced clinics outside the city itself.
Memphis · Jackson
Tennessee runs roughly 440 miles end to end, and providers cluster in Nashville, Knoxville, Chattanooga and Memphis. On the Cumberland Plateau, in the far north-west counties and across the Appalachian east, one-way drives of 60 to 120 minutes or more are routine. That matters more than it sounds: an infusion course is typically six sessions over two to three weeks, and every Spravato visit needs a driver because you cannot drive afterwards. If you live near the Kentucky, Georgia, Alabama, Mississippi, Arkansas or Missouri line, a clinic across the border may genuinely be closer — though your insurance network may not follow you there.
Tennessee borders KY, VA, NC, GA, AL, MS, AR, MO. A clinic across the border may be closer than one in your own state — but check that it is in your insurance network first, and note that a clinician must be licensed where you receive care.
In Tennessee, medical doctors and osteopathic physicians may administer ketamine within their scope of practice. An advanced practice registered nurse may prescribe Schedule II to V controlled substances only while holding a certificate of fitness from the Board of Nursing and having filed notice naming a collaborating physician, who keeps responsibility for prescribing. A physician assistant may prescribe them only as delegated by their primary collaborating physician. as of 8 Oct 2024 · Tennessee Code Annotated (source 1, opens in a new tab)
Spravato does not appear on TennCare's preferred drug list or its clinical criteria at all. That is not the same as TennCare refusing to cover it: TennCare routes medicines that a provider administers to the medical benefit, where your own managed care organisation decides coverage rather than the pharmacy list. The practical answer is to ask your TennCare plan, not your pharmacy. as of 15 Jul 2026 · State of Tennessee, Division of TennCare (source 1, opens in a new tab)We confirmed the absence by searching the full text of both TennCare documents. The conclusion that coverage sits with the managed care organisation follows from the preferred drug list's own stated rule for provider-administered medicines.
On 17 January 2025 the FDA approved Spravato for treatment-resistant depression in adults either on its own or together with an oral antidepressant, so a companion oral antidepressant is now optional for this use — though it is still permitted. as of 17 Jan 2025 · U.S. Food and Drug Administration (source 1, opens in a new tab)This applies to the treatment-resistant depression indication only. The separate indication for major depressive disorder with acute suicidal ideation still requires an oral antidepressant — see spravato.approval_mdd_si. Widely-cited secondary sources give 21 January 2025; that is the manufacturer's announcement date, not the FDA action date on the approval letter.
After a Spravato dose you must not drive or operate machinery until the next day, following a restful night's sleep, so you need to arrange a ride home from every session. as of 30 Apr 2025 · U.S. Food and Drug Administration (source 2, opens in a new tab)
Only esketamine (Spravato) is FDA-approved to treat depression. Racemic ketamine given by IV, injection, or under the tongue has no FDA approval for any psychiatric condition and is used off-label — that is, an approved drug used for an unapproved purpose. as of 30 Apr 2025 · U.S. Food and Drug Administration (source 1, opens in a new tab)
Tennessee does not require an in-person examination before a provider-patient relationship is established or before controlled substances are prescribed by telemedicine. Telehealth providers are held to the same standard of care as they would be in person. as of 2 Jan 2024 · Tennessee Code Annotated (source 6, opens in a new tab)Federal DEA telemedicine flexibilities run separately and expire at the end of 2026. Spravato cannot be prescribed for home use in any case, because it must be given in a certified setting.
No routine check is required. Ketamine is a Schedule III medicine and is not an opioid, a benzodiazepine, or a Schedule II amphetamine, so it falls outside the classes that trigger Tennessee's consultation duty. A narrower duty still applies if a practitioner knows or reasonably believes a patient is seeking drugs for misuse or diversion. as of 26 Jan 2022 · Tennessee Secretary of State (source 5, opens in a new tab)
Spravato does not appear on TennCare's preferred drug list or its clinical criteria at all. That is not the same as TennCare refusing to cover it: TennCare routes medicines that a provider administers to the medical benefit, where your own managed care organisation decides coverage rather than the pharmacy list. The practical answer is to ask your TennCare plan, not your pharmacy. as of 15 Jul 2026 · State of Tennessee, Division of TennCare (source 4, opens in a new tab)We confirmed the absence by searching the full text of both TennCare documents. The conclusion that coverage sits with the managed care organisation follows from the preferred drug list's own stated rule for provider-administered medicines.
A 2026 guide to ketamine therapy in Tennessee: state board licensing, TennCare coverage for Spravato, and what to look for in a qualified provider.
Tennessee has a growing number of ketamine clinics. Here is what to ask about credentials, safety protocols, and BCBS of Tennessee or TennCare coverage before you start.
How Spravato coverage works in Tennessee in 2026: TennCare prior auth, BlueCross BlueShield of Tennessee requirements, and practical steps for patients.